Keep the Heroes Out!
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Can a Defend card be played during another player's turn, when a hero attacks?
The designer answered this on BGG, and the rulebook describes Defend as a reaction to a hero's attack.
- brueh · Designer · 2023-09-23
- Keep the Heroes Out! rulebook · Rulebook · Actions
Yes. A Defend card can be played out of turn as a reaction to a single attack.