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Can you mix base game and Ancestors tribe and animal cards, by colour or card type, in the setup piles or in one game?

Yes, by swapping whole sets: you may replace a colour's or a designation's cards with their Ancestors versions, one complete set at a time, and each action column uses one tribe. The designer advises against shuffling all base and Ancestors cards into shared piles, especially animals, because it breaks the game.

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